Congratulations to Fabiana for her first article and thanks to Neauvia for this great collaboration! In the frame of a specific doctoral school program (PON Programma Operativo Nazionale) which aims to develop Innovation and Green methodologies with industrial partners, Fabiana could spend part of her PhD in Geneva and later on in Pavia. A great opportunity to develop safer, greener and innovative technologies through applied Science.
A LC-QTOF Method for the Determination of PEGDE Residues in Dermal Fillers
Hyaluronic acid is one of the most important ingredients in dermal fillers, where it is often cross-linked to gain more favorable rheological properties and to improve the implant duration. Poly(ethylene glycol) diglycidyl ether (PEGDE) has been recently introduced as a crosslinker because of its very similar chemical reactivity with the most-used crosslinker BDDE, while giving special rheological properties. Monitoring the amount of the crosslinker residues in the final device is always necessary, but in the case of PEGDE, no methods are available in literature. Here, we present an HPLC-QTOF method, validated according to the guidelines of the International Council on Harmonization, which enables the efficient routine examination of the PEGDE content in HA hydrogels.
